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95. Grodsky L, Wilson M, Rathinasabapathy T, Komarnytsky S (2024) Triptolide administration alters immune responses to mitigate insulin resistance in obese states. Biomolecules 14(4): 395 •

94. Tanveer M, Shehzad A, Komarnytsky S, Butt MS, Shahid M, Aadil RM (2024) Comparative evaluation of the antioxidant and anti-inflammatory potential of fennel essential oil obtained by conventional and supercritical fluid extraction. Biomass Conv Bioref XXX: XXX •

93. Surzenko N, Bastidas J, Reid RW, Curaba J, Zhang W, Bostan H, Wilson M, Dominique A, Roberson J, Ignacio G, Komarnytsky S, Sanders A, Lambirth K, Brouwer CR, El-Khodor BF (2024) Functional recovery following traumatic brain injury in rats is enhanced by oral supplementation with bovine thymus extract. FASEB J 38(3): e23460 •

92. Milhem F, Hamilton LM, Skates E, Wilson M, Johanningsmeier SD, Komarnytsky S (2024) Biomarkers of metabolic adaptation to high dietary fats in a mouse model of obesity resistance. Metabolites 14(1): 69 •

91. Milhem F, Skates E, Wilson M, Komarnytsky S (2024) Obesity-resistant mice on a high-fat diet display a distinct phenotype linked to enhanced lipid metabolism. Nutrients 16(1): 171 •

*** IJMS Special Issue (open for submission) Botanicals in Human Health



90. Milhem F, Komarnytsky S (2023) Progression to obesity: variations in patterns of metabolic fluxes, fat accumulation, and gastrointestinal responses. Metabolites 13(9): 1016 •

89. Carlisle C, Polley K, Panda C, Barron K, Hamrock M, Dominique A, Metzger B, Le Brun-Blashka S, Komarnytsky S (2023) Alleviation of pain, pain interference, and oxidative stress by a novel combination of hemp oil, calamari oil, and broccoli: a randomized, double-blind, placebo-controlled trial. Nutrients 15(12): 2654 •

88. Panda C, Komarnytsky S, Fleming MN, Marsh C, Barron K, Le Brun-Blashka S, Metzger B (2023) Guided metabolic detoxification program supports phase II detoxification enzymes and antioxidant balance in healthy participants. Nutrients 15(9): 2209 •

87. Balfany C, Gutierrez J, Moncada M, Komarnytsky S (2023) Current status and nutritional value of green leaf protein. Nutrients 15(6): 1327 •

86. Garcia D, You SW, Aleman RS, King JM, Komarnytsky S, Hoskin RT, Moncada M (2023) Total utilization-upcycling of mushroom protein by-product: characterization and assessment as an alternative batter ingredient for fried shrimp. Foods 12: 763 •

85. Komarnytsky S, Wagner C, Gutierrez J, Shaw OM (2023) Berries in microbiome-mediated gastrointestinal, metabolic, and immune health. Curr Nutr Rep 12: 151-166 •

84. Alghamdi M, Gutierrez J, Komarnytsky S (2023) Essential minerals and metabolic adaptation of immune cells. Nutrients 15(1):123 •

*** IJMS Special Issue (completed) Natural Product Pharmacology 2.0



83. Alvarenga ES, Ribeiro NC, Demuner AJ, Cerceau CI, Dos Santos MH, Komarnytsky S (2022) Indicators of plant-insect relationship by analysis of floral scent volatiles from three Plumeria species. Conjecturas 22(16): 445-453 •

82. You SW, Hoskin RT, Komarnytsky S, Moncada M (2022) Mushrooms as functional and nutritious food ingredients for multiple applications. ACS Food Sci Technol 2(8): 1184-1195 •

81. Rathinasabapathy T, Lomax J, Srikanth K, Esposito D, Kay CD, Komarnytsky S (2022) Effect of wild blueberry metabolites on biomarkers of gastrointestinal and immune health in vitro. Immuno 2(2): 293-306 •

80. Vong CI, Rathinasabapathy T, Moncada M, Komarnytsky S (2022) All polyphenols are not created equal: exploring the diversity of phenolic metabolites. J Agric Food Chem 70(7): 2077-2091 •

79. Rathinasabapathy T, Sakthivel LP, Komarnytsky S (2022) Plant-based support of respiratory health during viral outbreaks. J Agric Food Chem 70(7): 2064-2076 •

78. Komarnytsky S, Retchin S, Vong CI, Lila MA (2022) Gains and losses of agricultural food production: implications for the twenty-first century. Ann Rev Food Sci Tech 13: 239-261 •



77. Esposito LGA, Overbaugh E, Xiong J, Rathinasabapathy T, Komarnytsky S, da Silva DJH, Esposito D (2021) Immune responses are differentially regulated by root, stem, leaf, and flower extracts of female and male CBD Hemp (Cannabis sativa L.) plants. Immuno 1(4): 369-379 •

76. Chiang N, Ray S, Lomax J, Goertzen S, Komarnytsky S, Ho CT, Munafo JP (2021) Modulation of brain-derived neurotrophic factor (BDNF) signaling pathway by culinary sage (Salvia officinalis L.). Int J Mol Sci 22(14): 7382 •

75. Komarnytsky S, Rathinasabapathy T, Wagner C, Metzger B, Carlisle C, Panda C, Le Brun-Blashka S, Troup JP, Varadharaj S (2021) Endocannabinoid system and its regulation by polyunsaturated fatty acids and full spectrum hemp oils. Int J Mol Sci 22: 5479 •

74. Wilson M, Konda V, Heidt K, Rathinasabapathy T, Desai A, Komarnytsky S (2021) Rheum rhaponticum root extract improves vasomotor menopausal symptoms and estrogen-regulated targets in ovariectomized rat model. Int J Mol Sci 22: 1032 •

*** IJMS Special Issue (completed) Natural Product Pharmacology



73. Xiong J, Chan YS, Rathinasabapathy T, Grace MH, Komarnytsky S, Lila MA (2020) Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model. Food Chem 331: 127279 •

72. Di R, Murray AF, Xiong J, Esposito D, Komarnytsky S, Gianfagna TJ, Munafo JP (2020) Lily steroidal glycoalkaloid promotes early inflammatory resolution in wounded human fibroblasts. J Ethnopharmacol 258: 112766 •

71. Moore EM, Wagner C, Komarnytsky S (2020) The enigma of bioactivity and toxicity of botanical oils for skin care. Frontiers Pharmacol 11: 785 •

70. Wagner C, De Gezelle J, Komarnytsky S (2020) Celtic provenance in traditional herbal medicine of Medieval Wales and classical antiquity. Frontiers Pharmacol 11: 105 •

69. Tanveer M, Wagner C, ul Haq MI, Ribeiro NC, Rathinasabapathy T, Butt MS, Shehzad A, Komarnytsky S (2020) Spicing up gastrointestinal health with dietary essential oils. Phytochemistry Rev 19(2): 243-263 •



68. De Canha MN, Komarnytsky S, Langhansova L, Lall N (2019) Exploring the anti-acne potential of impepho (Helichrysum odoratissimum) to combat Cutibacterium acnes virulence. Frontiers Pharmacol 10: 1559

67. Esposito D, Overall J, Grace M, Komarnytsky S, Lila MA (2019) Alaskan berry extracts promote dermal wound repair through modulation of bioenergetics and integrin signaling. Frontiers Pharmacol 10: 1058

66. Murray AF, Palatini K, Komarnytsky S, Gianfagna TJ, Munafo JP (2019) Phenylpropanoid glycerol glucosides attenuate glucose production in hepatocytes. ACS Omega 4(6): 10670-10676



65. Palatini K, Komarnytsky S (2018) The quality, safety, and efficacy of botanical drugs. In: Botanical Drug Products: Recent Developments and Market Trends (Eds: Lokhande JN, Pathak YV), CRC Press, pp. 159-186

64. Kozlowska W, Wagner C, Moore EM, Matkowski A, Komarnytsky S (2018) Botanical provenance of traditional medicines from Carpathian Mountains at the Ukrainian-Polish border. Frontiers Pharmacol 9: 295

63. Ribeiro NC, Demuner AJ, dos Santos MH, Maltha CRA, de Alvarenga EA, Komarnytsky S (2018) Metals complexes formed with oleanolic acid. Int J Org Chem 8: 160-169

62. Skates E, Overall J, DeZego K, Wilson M, Esposito D, Lila MA, Komarnytsky S (2018) Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage. Food Chem Toxicol 111: 445-453

61. Bolin JF, Hartwig CL, Schafran PW, Komarnytsky S (2018) Application of DNA flow cytometry to aid species delimitation in Isoetes. Castanea 83(1): 38-47



60. Xiong J, Grace MH, Esposito D, Komarnytsky S, Wang F, Lila MA (2017) Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities. Chin J Nat Med. 15(11): 816-824

59. Graf BL, Kamat S, Cheong KY, Komarnytsky S, Driscoll M, Di R (2017) Phytoecdysteroid-enriched quinoa seed leachate enhances healthspan and mitochondrial metabolism in Caenorhabditis elegans. J Functional Foods 37: 1-7

58. Kandasamy M, Salihin M, Pichika MR, Komarnytsky S, Rathinasabapathy T (2017) A metabolic stability determination of tetrahydrothiazolopyridine derivative as a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. Int J Pharm Bio Sci 8(3): 120-130

57. Rathinasabapathy T, Palatini Jackson KM, Thor Y, Buru AS, Esposito D, Li X, Pichika MR, Hamzah AS, Komarnytsky S (2017) Thiazolopyridines improve adipocyte function by inhibiting 11 beta-HSD1 oxoreductase activity. Hindawi J Chem 2017: 3182129

56. Jackson Palatini KM, Rathinasabapathy T, Esposito D, Komarnytsky S (2017) Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory. Mol Nutr Food Res 61(9): 1601118

55. Wagner C, De Gezelle J, Robertson M, Robertson K, Wilson M, Komarnytsky S (2017) Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript. J Ethnopharmacol 203: 171-181

54. Overall J, Lila MA, Komarnytsky S (2017) Anthocyanins in metabolic health and disease. In: Nutrigenomics and Proteomics in Health and Disease (Eds: Kussmann M, Stiver P), Wiley, pp. 92-123

53. Overall J, Bonney SA, Wilson M, Beermann A, Grace MH, Esposito D, Lila MA, Komarnytsky S (2017) Metabolic effects of berries with structurally diverse anthocyanins. Int J Mol Sci 18(2): 422



52. Alexyuk MS, Alexyuk PG, Bogoyavlenskiy AP, Zhumanov ZZ, Turmagambetova AS, Berezin VE, Komarnytsky S, Mirzadinov RA (2016) Diversity of viral photosystem-II psb a genes in the largest channel reservoir of Kazakhstan. Res J Pharmaceut Biol Chem Sci 7(3): 2674-2680

51. Grace MH, Esposito D, Timmers MA, Xiong J, Yousef G, Komarnytsky S, Lila MA (2016) In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents. Food & Function 7(10): 4285-4298

50. Grace MH, Esposito D, Timmers MA, Xiong J, Yousef G, Komarnytsky S, Lila MA (2016) Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts. Food Chem 210(44): 85-95



49. Tang W, Munafo JP Jr, Palatini K, Esposito D, Huang MT, Komarnytsky S, Ho CT, Gianfagna TJ (2015) Hepatoprotective activity of Easter lily (Lilium longiflorum Thunb) bulb extracts. J Agric Food Chem 63(44): 9722-9728

48. Esposito D, Damsud T, Wilson M, Grace MH, Strauch R, Li X, Lila MA, Komarnytsky S (2015) Blackcurrant anthocyanins attenuate weight gain and improve glucose metabolism in diet-induced obese mice with intact, but not disrupted, gut microbiome. J Agric Food Chem 63(27): 6172-6180

47. Kellogg J, Esposito D, Grace MH, Komarnytsky S, Lila MA (2015) Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes. J Functional Foods 15: 396–407

46. Bussler W, Hildebrand J, Mixon C, Wagoner T, Komarnytsky S, Harris GK (2015) Flavonoid supplementation and cardiovascular disease. In: Dietary supplements in health promotion (Ed: Wallace TC), CRC Press, pp. 281-317

45. Ricciardi CJ, Bae J, Esposito D, Komarnytsky S, Hu P, Chen J, Zhao L (2015) 1,25-Dihydroxyvitamin D3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration. Eur J Nutr 54(6):1001-1012



44. Le V, Esposito D, Grace M, Ha D, Pham A, Bortolazzo A, Kim J, Okuda R, Komarnytsky S, Lila MA, White B (2014) Cytotoxic effects of ellagitannins isolated from walnuts in human cancer cells. Nutr Cancer 66: 1304-1314

43. Bae J, Ricciardi CJ, Esposito D, Komarnytsky S, Hu P, Curry B, Brown PL, Gao Z, Biggerstaff JP, Chen J, Zhao L (2014) Activation of pattern recognition receptors in brown adipocytes induce inflammation and suppress uncoupling protein 1 expression and mitochondrial respiration. Am J Physiol Cell Physiol 306(10): C918-C930

42. Esposito D, Chen A, Grace MH, Komarnytsky S, Lila MA (2014) Inhibitory effects of wild blueberry anthocyanins and other flavonoids on biomarkers of acute and chronic inflammation in vitro. J Agric Food Chem 62(29): 7022–7028



41. Esposito D, Rathinasabapathy T, Schmidt B, Shakarjian MP, Komarnytsky S, Raskin I (2013) Acceleration of cutaneous wound healing by brassinosteroids. Wound Repair Regen 21(5): 688-696

40. Esposito D, Munafo JP, Lucibello T, Baldeon M, Komarnytsky S, Gianfagna TJ (2013) Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro. J Ethnopharmacol 148: 433-440

39. Komarnytsky S, Esposito D, Rathinasabapathy T, Poulev A, Raskin I (2013) Effects of pregnane glycosides on food intake depend on stimulation of melanocortin pathway and BDNF in animal model. J Agric Food Chem 61(8): 1841-1849

38. Komarnytsky S, Esposito D, Poulev A, Raskin I (2013) Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells. J Cell Physiol 228(5): 1120-1126



37. Esposito D, Kizelsztein P, Komarnytsky S, Raskin I (2012) Hypoglycemic effects of brassinosteroid in diet-induced obese mice. AJP Endocrinol Metabol 303(5): E652-658

36. Komarnytsky S, Borisjuk N (2012) Plant-derived antibodies for academic, industrial, and therapeutic applications. In: Antibody mediated drug discovery systems (Eds: Pathak Y, Benita S), John Wiley & Sons, pp 365-381



35. Esposito D, Komarnytsky S, Shapses S, Raskin I (2011) Anabolic effect of plant brassinosteroid. FASEB J 25(10): 3708-3719

34. Esposito D, Rathinasabapathy T, Poulev A, Komarnytsky S, Raskin I (2011) Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J Med Chem 54: 4057-4066

33. Komarnytsky S, Cook A, Raskin I (2011) Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism. Int J Obes 35(2): 236-243



32. Kellogg J, Joseph G, Andrae-Marobela K, Sosome A, Flint C, Kormarnytsky S, Fear G, Struwe L, Raskin I, and Lila MA (2010) Simple, predictive field bioassays enable transdisciplinary science education and lead students in the quest for biodiscovery. NACTA Journal 54: 41-48



31. Kizelsztein P, Komarnytsky S, Raskin I (2009) Oral administration of triptolide ameliorates clinical symptoms of experimental autoimmune encephalomyelitis by induction of Hsp70 and stabilization of NF-kB /IkBa. J Neuroimmunol 217(1-2): 28-37

30. Kizelsztein P, Govorko D, Komarnytsky S, Evans A, Wang Z, Cefalu WT, Raskin I (2009) 20-hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. Am J Physiol Endocrinol Metab 296(3): E433-439



29. Fear G, Komarnytsky S, Raskin I (2007) Protease inhibitors and their peptidomimetic derivatives as potential drugs. Pharmacology and Therapeutics 113(2): 354-368

28. Govorko D, Logendra S, Wang Y, Esposito D, Komarnytsky S, Ribnicky D, Poulev A, Wang Z, Cefalu WT, Raskin I (2007) Polyphenolic compounds from Artemisia dracunculus inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. Am J Physiol Endocrinol Metab 293(6): E1503-1510

27. Okunji C, Komarnytsky S, Fear G, Poulev A, Ribnicky DM, Awachie PI, Ito Y, Raskin I (2007) Preparative isolation and identification of tyrosinase inhibitors from seeds of Garcinia kola by HSCCC chromatography. J Chromatogr A 1151(1-2): 45-50



26. Komarnytsky S, Borisjuk N, Yakoby N, Garvey A, Raskin I (2006) Co-secretion of protease inhibitor stabilizes antibodies produced by plant roots. Plant Physiology 141: 1185-1193



25. Komarnytsky S (2005) Molecular phylogeny of chloroplast DNA of Nicotiana species. Cytol Genet 39(4): 13-19



24. Komarnytsky S, Gaume A, Garvey A, Borisjuk N, Raskin I (2004) Quick and efficient system for antibiotic-free expression of heterologous genes in tobacco roots. Plant Cell Reports 22: 765-773

23. Komarnytsky S, Komarnytsky I (2004) Genetic variability among Solanum and Lycopersion species revealed by amplified fragment restriction polymorphysm analysis of chloroplast DNA. Cytol Genet 38(5): 9-15



22. Komarnytsky S, Borisjuk N (2003) Functional analysis of promoter elements in plants. Genetic Engineering 25: 113-141. Kluwer Academic Publishers, New York

21. Gaume A, Komarnytsky S, Borisjuk N, Raskin I (2003) Rhizosecretion of recombinant proteins from plant hairy roots. Plant Cell Reports 21: 1188-1193

20. Komarnytsky S, Komarnytsky I (2003) Restriction variability of amplified chloroplast DNA fragments in the genus Nicotiana. Cytol Genet 37(1): 18-23

19. Komarnytsky S, Komarnytsky I (2003) Phylogenetic analysis of chloroplast DNA of 18 Solanaceae species. Cytol Genet 37(6): 17-22



18. Komarnytsky S, Komarnytsky I (2002) Restriction polymorphism of amplified fragments of the genus Nicotiana chloroplast DNA. Biopolym Cell 18(6): 485-488

17. Raskin I, Ribnicky DM, Komarnytsky S, Ilic N, Poulev A, Borisjuk N, Brinker A, Moreno DA, Ripoll C, Yakoby N, O’Neal JM, Cornwell T, Pastor I, Fridlender B (2002) Plants and human health in the twenty-first century. Trends in Biotechnology 20: 522-531

16. Komarnytsky S, Komarnytsky I (2002) Amplification of randomly polymorphic DNA of American tobaccos from Petunioides subgenus. Biopolym Cell 18(4): 283-286



15. Komarnytsky S, Komarnytsky I (2001) Phylogenetic tree of the australian species of Nicotiana based on the random amplified polymorphic DNA. Biopolym Cell 17(4): 278-282

14. Komarnytsky S (2001) Restriction enzyme mapping of ribosomal RNA genes of genus Nicotiana. Biopolym Cell 17(5): 380-387



13. Komarnytsky S, Borisjuk N, Borisjuk L, Alam M, Raskin I (2000) Production of recombinant proteins in tobacco guttation fluid. Plant Physiology 124: 927-933

12. Borisjuk N, Borisjuk L, Komarnytsky S, Timeva S, Hemleben V, Gleba Yu, Raskin I (2000) Tobacco ribosomal DNA spacer element stimulates amplification and expression of heterologous genes. Nature Biotechnology 18: 1303-1306

11. Komarnytsky S, Komarnytsky I (2000) Organization and evolution of the Nicotiana 5S rRNA genes. Biopolym Cell 16(3): 205-211

10. Komarnytsky S (2000) Subrepeats of the intergenic spacer of Nicotiana ribosomal DNA. Biopolym Cell 16(2): 108-114



9. Komarnytsky S (1999) An attempt to combine morphological characters and nuclear ribosomal DNA (internal transcribed spacer) sequences in phylogenetic studies in the genus Nicotiana. Biopolym Cell 15(5): 383-389

8. Komarnytsky S (1999) Restriction mapping of ribosomal DNA repeats of 18 Solanaceae species. Biopolym Cell 15(3): 213-218



7. Komarnytsky S, Komarnytsky I, Cox A, Parokonny AS (1998) Molecular phylogeny of the nuclear 5.8S ribosomal RNA gene in 37 species of Nicotiana genus. Russian J Genet 34(7): 727-733

6. Komarnytsky S, Komarnytsky I, Cox A, Parokonny AS (1998) Evolution of sequences of the internal spacer of nuclear ribosomal DNA of American species of the genus Nicotiana. Cytol Genet 32(3): 69-76

5. Komarnytsky S (1998) Comparative analysis of 5.8S rDNA sequences from higher plants. Reports Natl Acad Sci Ukraine 1: 190-193



4. Komarnytsky S (1997) Comparative analysis of nucleotide sequences of 5.8S nuclear ribosomal DNA of 30 plant species. Biopolym Cell 13(2): 150-156

3. Komarnytsky S, Komarnytsky I, Cox A, Parokonny AS (1997) Variation in 5.8S rDNA in some Solanaceae species. Cytol Genet 31(5): 11-19

2. Komarnytsky I, Komarnytsky S (1997) Variation in the intergenic spacer of ribosomal DNA of American species of tobacco. Cytol Genet 31(2): 29-36



1. Komarnytsky I, Komarnytsky S (1996) Restriction fragment length polymorphism of the intergenic spacer of ribosomal DNA of some tobacco species. Cytol Genet 30(1): 65-72