Google Scholar • LinkedIn • ORCID • Pubmed • Research Gate
2024
95. Grodsky L, Wilson M, Rathinasabapathy T, Komarnytsky S (2024) Triptolide administration alters immune responses to mitigate insulin resistance in obese states. Biomolecules 14(4): 395 • https://doi.org/10.3390/biom14040395
94. Tanveer M, Shehzad A, Komarnytsky S, Butt MS, Shahid M, Aadil RM (2024) Comparative evaluation of the antioxidant and anti-inflammatory potential of fennel essential oil obtained by conventional and supercritical fluid extraction. Biomass Conv Bioref XXX: XXX • https://doi.org/10.1007/s13399-024-05405-8
93. Surzenko N, Bastidas J, Reid RW, Curaba J, Zhang W, Bostan H, Wilson M, Dominique A, Roberson J, Ignacio G, Komarnytsky S, Sanders A, Lambirth K, Brouwer CR, El-Khodor BF (2024) Functional recovery following traumatic brain injury in rats is enhanced by oral supplementation with bovine thymus extract. FASEB J 38(3): e23460 • https://doi.org/10.1096/fj.202301859R
92. Milhem F, Hamilton LM, Skates E, Wilson M, Johanningsmeier SD, Komarnytsky S (2024) Biomarkers of metabolic adaptation to high dietary fats in a mouse model of obesity resistance. Metabolites 14(1): 69 • https://doi.org/10.3390/metabo14010069
91. Milhem F, Skates E, Wilson M, Komarnytsky S (2024) Obesity-resistant mice on a high-fat diet display a distinct phenotype linked to enhanced lipid metabolism. Nutrients 16(1): 171 • https://doi.org/10.3390/nu16010171
*** IJMS Special Issue (open for submission) Botanicals in Human Health
2023
90. Milhem F, Komarnytsky S (2023) Progression to obesity: variations in patterns of metabolic fluxes, fat accumulation, and gastrointestinal responses. Metabolites 13(9): 1016 • https://doi.org/10.3390/metabo13091016
89. Carlisle C, Polley K, Panda C, Barron K, Hamrock M, Dominique A, Metzger B, Le Brun-Blashka S, Komarnytsky S (2023) Alleviation of pain, pain interference, and oxidative stress by a novel combination of hemp oil, calamari oil, and broccoli: a randomized, double-blind, placebo-controlled trial. Nutrients 15(12): 2654 • https://doi.org/10.3390/nu15122654
88. Panda C, Komarnytsky S, Fleming MN, Marsh C, Barron K, Le Brun-Blashka S, Metzger B (2023) Guided metabolic detoxification program supports phase II detoxification enzymes and antioxidant balance in healthy participants. Nutrients 15(9): 2209 • https://doi.org/10.3390/nu15092209
87. Balfany C, Gutierrez J, Moncada M, Komarnytsky S (2023) Current status and nutritional value of green leaf protein. Nutrients 15(6): 1327 • https://doi.org/10.3390/nu15061327
86. Garcia D, You SW, Aleman RS, King JM, Komarnytsky S, Hoskin RT, Moncada M (2023) Total utilization-upcycling of mushroom protein by-product: characterization and assessment as an alternative batter ingredient for fried shrimp. Foods 12: 763 • https://doi.org/10.3390/foods12040763
85. Komarnytsky S, Wagner C, Gutierrez J, Shaw OM (2023) Berries in microbiome-mediated gastrointestinal, metabolic, and immune health. Curr Nutr Rep 12: 151-166 • https://doi.org/10.1007/s13668-023-00449-0
84. Alghamdi M, Gutierrez J, Komarnytsky S (2023) Essential minerals and metabolic adaptation of immune cells. Nutrients 15(1):123 • https://doi.org/10.3390/nu15010123
*** IJMS Special Issue (completed) Natural Product Pharmacology 2.0
2022
83. Alvarenga ES, Ribeiro NC, Demuner AJ, Cerceau CI, Dos Santos MH, Komarnytsky S (2022) Indicators of plant-insect relationship by analysis of floral scent volatiles from three Plumeria species. Conjecturas 22(16): 445-453 • http://dx.doi.org/10.53660/CONJ-2025-2S01
82. You SW, Hoskin RT, Komarnytsky S, Moncada M (2022) Mushrooms as functional and nutritious food ingredients for multiple applications. ACS Food Sci Technol 2(8): 1184-1195 • https://doi.org/10.1021/acsfoodscitech.2c00107
81. Rathinasabapathy T, Lomax J, Srikanth K, Esposito D, Kay CD, Komarnytsky S (2022) Effect of wild blueberry metabolites on biomarkers of gastrointestinal and immune health in vitro. Immuno 2(2): 293-306 • https://doi.org/10.3390/immuno2020019
80. Vong CI, Rathinasabapathy T, Moncada M, Komarnytsky S (2022) All polyphenols are not created equal: exploring the diversity of phenolic metabolites. J Agric Food Chem 70(7): 2077-2091 • https://doi.org/10.1021/acs.jafc.1c07179
79. Rathinasabapathy T, Sakthivel LP, Komarnytsky S (2022) Plant-based support of respiratory health during viral outbreaks. J Agric Food Chem 70(7): 2064-2076 • https://doi.org/10.1021/acs.jafc.1c06227
78. Komarnytsky S, Retchin S, Vong CI, Lila MA (2022) Gains and losses of agricultural food production: implications for the twenty-first century. Ann Rev Food Sci Tech 13: 239-261 • https://doi.org/10.1146/annurev-food-082421-114831
2021
77. Esposito LGA, Overbaugh E, Xiong J, Rathinasabapathy T, Komarnytsky S, da Silva DJH, Esposito D (2021) Immune responses are differentially regulated by root, stem, leaf, and flower extracts of female and male CBD Hemp (Cannabis sativa L.) plants. Immuno 1(4): 369-379 • https://doi.org/10.3390/immuno1040025
76. Chiang N, Ray S, Lomax J, Goertzen S, Komarnytsky S, Ho CT, Munafo JP (2021) Modulation of brain-derived neurotrophic factor (BDNF) signaling pathway by culinary sage (Salvia officinalis L.). Int J Mol Sci 22(14): 7382 • https://doi.org/10.3390/ijms22147382
75. Komarnytsky S, Rathinasabapathy T, Wagner C, Metzger B, Carlisle C, Panda C, Le Brun-Blashka S, Troup JP, Varadharaj S (2021) Endocannabinoid system and its regulation by polyunsaturated fatty acids and full spectrum hemp oils. Int J Mol Sci 22: 5479 • https://doi.org/10.3390/ijms22115479
74. Wilson M, Konda V, Heidt K, Rathinasabapathy T, Desai A, Komarnytsky S (2021) Rheum rhaponticum root extract improves vasomotor menopausal symptoms and estrogen-regulated targets in ovariectomized rat model. Int J Mol Sci 22: 1032 • https://doi.org/10.3390/ijms22031032
*** IJMS Special Issue (completed) Natural Product Pharmacology
2020
73. Xiong J, Chan YS, Rathinasabapathy T, Grace MH, Komarnytsky S, Lila MA (2020) Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model. Food Chem 331: 127279 • https://doi.org/10.1016/j.foodchem.2020.127279
72. Di R, Murray AF, Xiong J, Esposito D, Komarnytsky S, Gianfagna TJ, Munafo JP (2020) Lily steroidal glycoalkaloid promotes early inflammatory resolution in wounded human fibroblasts. J Ethnopharmacol 258: 112766 • https://doi.org/10.1016/j.jep.2020.112766
71. Moore EM, Wagner C, Komarnytsky S (2020) The enigma of bioactivity and toxicity of botanical oils for skin care. Frontiers Pharmacol 11: 785 • https://doi.org/10.3389/fphar.2020.00785
70. Wagner C, De Gezelle J, Komarnytsky S (2020) Celtic provenance in traditional herbal medicine of Medieval Wales and classical antiquity. Frontiers Pharmacol 11: 105 • https://doi.org/10.3389/fphar.2020.00105
69. Tanveer M, Wagner C, ul Haq MI, Ribeiro NC, Rathinasabapathy T, Butt MS, Shehzad A, Komarnytsky S (2020) Spicing up gastrointestinal health with dietary essential oils. Phytochemistry Rev 19(2): 243-263 • https://doi.org/10.1007/s11101-020-09664-x
2019
68. De Canha MN, Komarnytsky S, Langhansova L, Lall N (2019) Exploring the anti-acne potential of impepho (Helichrysum odoratissimum) to combat Cutibacterium acnes virulence. Frontiers Pharmacol 10: 1559
67. Esposito D, Overall J, Grace M, Komarnytsky S, Lila MA (2019) Alaskan berry extracts promote dermal wound repair through modulation of bioenergetics and integrin signaling. Frontiers Pharmacol 10: 1058
66. Murray AF, Palatini K, Komarnytsky S, Gianfagna TJ, Munafo JP (2019) Phenylpropanoid glycerol glucosides attenuate glucose production in hepatocytes. ACS Omega 4(6): 10670-10676
2018
65. Palatini K, Komarnytsky S (2018) The quality, safety, and efficacy of botanical drugs. In: Botanical Drug Products: Recent Developments and Market Trends (Eds: Lokhande JN, Pathak YV), CRC Press, pp. 159-186
64. Kozlowska W, Wagner C, Moore EM, Matkowski A, Komarnytsky S (2018) Botanical provenance of traditional medicines from Carpathian Mountains at the Ukrainian-Polish border. Frontiers Pharmacol 9: 295
63. Ribeiro NC, Demuner AJ, dos Santos MH, Maltha CRA, de Alvarenga EA, Komarnytsky S (2018) Metals complexes formed with oleanolic acid. Int J Org Chem 8: 160-169
62. Skates E, Overall J, DeZego K, Wilson M, Esposito D, Lila MA, Komarnytsky S (2018) Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage. Food Chem Toxicol 111: 445-453
61. Bolin JF, Hartwig CL, Schafran PW, Komarnytsky S (2018) Application of DNA flow cytometry to aid species delimitation in Isoetes. Castanea 83(1): 38-47
2017
60. Xiong J, Grace MH, Esposito D, Komarnytsky S, Wang F, Lila MA (2017) Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities. Chin J Nat Med. 15(11): 816-824
59. Graf BL, Kamat S, Cheong KY, Komarnytsky S, Driscoll M, Di R (2017) Phytoecdysteroid-enriched quinoa seed leachate enhances healthspan and mitochondrial metabolism in Caenorhabditis elegans. J Functional Foods 37: 1-7
58. Kandasamy M, Salihin M, Pichika MR, Komarnytsky S, Rathinasabapathy T (2017) A metabolic stability determination of tetrahydrothiazolopyridine derivative as a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. Int J Pharm Bio Sci 8(3): 120-130
57. Rathinasabapathy T, Palatini Jackson KM, Thor Y, Buru AS, Esposito D, Li X, Pichika MR, Hamzah AS, Komarnytsky S (2017) Thiazolopyridines improve adipocyte function by inhibiting 11 beta-HSD1 oxoreductase activity. Hindawi J Chem 2017: 3182129
56. Jackson Palatini KM, Rathinasabapathy T, Esposito D, Komarnytsky S (2017) Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory. Mol Nutr Food Res 61(9): 1601118
55. Wagner C, De Gezelle J, Robertson M, Robertson K, Wilson M, Komarnytsky S (2017) Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript. J Ethnopharmacol 203: 171-181
54. Overall J, Lila MA, Komarnytsky S (2017) Anthocyanins in metabolic health and disease. In: Nutrigenomics and Proteomics in Health and Disease (Eds: Kussmann M, Stiver P), Wiley, pp. 92-123
53. Overall J, Bonney SA, Wilson M, Beermann A, Grace MH, Esposito D, Lila MA, Komarnytsky S (2017) Metabolic effects of berries with structurally diverse anthocyanins. Int J Mol Sci 18(2): 422
2016
52. Alexyuk MS, Alexyuk PG, Bogoyavlenskiy AP, Zhumanov ZZ, Turmagambetova AS, Berezin VE, Komarnytsky S, Mirzadinov RA (2016) Diversity of viral photosystem-II psb a genes in the largest channel reservoir of Kazakhstan. Res J Pharmaceut Biol Chem Sci 7(3): 2674-2680
51. Grace MH, Esposito D, Timmers MA, Xiong J, Yousef G, Komarnytsky S, Lila MA (2016) In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents. Food & Function 7(10): 4285-4298
50. Grace MH, Esposito D, Timmers MA, Xiong J, Yousef G, Komarnytsky S, Lila MA (2016) Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts. Food Chem 210(44): 85-95
2015
49. Tang W, Munafo JP Jr, Palatini K, Esposito D, Huang MT, Komarnytsky S, Ho CT, Gianfagna TJ (2015) Hepatoprotective activity of Easter lily (Lilium longiflorum Thunb) bulb extracts. J Agric Food Chem 63(44): 9722-9728
48. Esposito D, Damsud T, Wilson M, Grace MH, Strauch R, Li X, Lila MA, Komarnytsky S (2015) Blackcurrant anthocyanins attenuate weight gain and improve glucose metabolism in diet-induced obese mice with intact, but not disrupted, gut microbiome. J Agric Food Chem 63(27): 6172-6180
47. Kellogg J, Esposito D, Grace MH, Komarnytsky S, Lila MA (2015) Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes. J Functional Foods 15: 396–407
46. Bussler W, Hildebrand J, Mixon C, Wagoner T, Komarnytsky S, Harris GK (2015) Flavonoid supplementation and cardiovascular disease. In: Dietary supplements in health promotion (Ed: Wallace TC), CRC Press, pp. 281-317
45. Ricciardi CJ, Bae J, Esposito D, Komarnytsky S, Hu P, Chen J, Zhao L (2015) 1,25-Dihydroxyvitamin D3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration. Eur J Nutr 54(6):1001-1012
2014
44. Le V, Esposito D, Grace M, Ha D, Pham A, Bortolazzo A, Kim J, Okuda R, Komarnytsky S, Lila MA, White B (2014) Cytotoxic effects of ellagitannins isolated from walnuts in human cancer cells. Nutr Cancer 66: 1304-1314
43. Bae J, Ricciardi CJ, Esposito D, Komarnytsky S, Hu P, Curry B, Brown PL, Gao Z, Biggerstaff JP, Chen J, Zhao L (2014) Activation of pattern recognition receptors in brown adipocytes induce inflammation and suppress uncoupling protein 1 expression and mitochondrial respiration. Am J Physiol Cell Physiol 306(10): C918-C930
42. Esposito D, Chen A, Grace MH, Komarnytsky S, Lila MA (2014) Inhibitory effects of wild blueberry anthocyanins and other flavonoids on biomarkers of acute and chronic inflammation in vitro. J Agric Food Chem 62(29): 7022–7028
2013
41. Esposito D, Rathinasabapathy T, Schmidt B, Shakarjian MP, Komarnytsky S, Raskin I (2013) Acceleration of cutaneous wound healing by brassinosteroids. Wound Repair Regen 21(5): 688-696
40. Esposito D, Munafo JP, Lucibello T, Baldeon M, Komarnytsky S, Gianfagna TJ (2013) Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro. J Ethnopharmacol 148: 433-440
39. Komarnytsky S, Esposito D, Rathinasabapathy T, Poulev A, Raskin I (2013) Effects of pregnane glycosides on food intake depend on stimulation of melanocortin pathway and BDNF in animal model. J Agric Food Chem 61(8): 1841-1849
38. Komarnytsky S, Esposito D, Poulev A, Raskin I (2013) Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells. J Cell Physiol 228(5): 1120-1126
2012
37. Esposito D, Kizelsztein P, Komarnytsky S, Raskin I (2012) Hypoglycemic effects of brassinosteroid in diet-induced obese mice. AJP Endocrinol Metabol 303(5): E652-658
36. Komarnytsky S, Borisjuk N (2012) Plant-derived antibodies for academic, industrial, and therapeutic applications. In: Antibody mediated drug discovery systems (Eds: Pathak Y, Benita S), John Wiley & Sons, pp 365-381
2011
35. Esposito D, Komarnytsky S, Shapses S, Raskin I (2011) Anabolic effect of plant brassinosteroid. FASEB J 25(10): 3708-3719
34. Esposito D, Rathinasabapathy T, Poulev A, Komarnytsky S, Raskin I (2011) Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J Med Chem 54: 4057-4066
33. Komarnytsky S, Cook A, Raskin I (2011) Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism. Int J Obes 35(2): 236-243
2010
32. Kellogg J, Joseph G, Andrae-Marobela K, Sosome A, Flint C, Kormarnytsky S, Fear G, Struwe L, Raskin I, and Lila MA (2010) Simple, predictive field bioassays enable transdisciplinary science education and lead students in the quest for biodiscovery. NACTA Journal 54: 41-48
2009
31. Kizelsztein P, Komarnytsky S, Raskin I (2009) Oral administration of triptolide ameliorates clinical symptoms of experimental autoimmune encephalomyelitis by induction of Hsp70 and stabilization of NF-kB /IkBa. J Neuroimmunol 217(1-2): 28-37
30. Kizelsztein P, Govorko D, Komarnytsky S, Evans A, Wang Z, Cefalu WT, Raskin I (2009) 20-hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. Am J Physiol Endocrinol Metab 296(3): E433-439
2007
29. Fear G, Komarnytsky S, Raskin I (2007) Protease inhibitors and their peptidomimetic derivatives as potential drugs. Pharmacology and Therapeutics 113(2): 354-368
28. Govorko D, Logendra S, Wang Y, Esposito D, Komarnytsky S, Ribnicky D, Poulev A, Wang Z, Cefalu WT, Raskin I (2007) Polyphenolic compounds from Artemisia dracunculus inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. Am J Physiol Endocrinol Metab 293(6): E1503-1510
27. Okunji C, Komarnytsky S, Fear G, Poulev A, Ribnicky DM, Awachie PI, Ito Y, Raskin I (2007) Preparative isolation and identification of tyrosinase inhibitors from seeds of Garcinia kola by HSCCC chromatography. J Chromatogr A 1151(1-2): 45-50
2006
26. Komarnytsky S, Borisjuk N, Yakoby N, Garvey A, Raskin I (2006) Co-secretion of protease inhibitor stabilizes antibodies produced by plant roots. Plant Physiology 141: 1185-1193
2005
25. Komarnytsky S (2005) Molecular phylogeny of chloroplast DNA of Nicotiana species. Cytol Genet 39(4): 13-19
2004
24. Komarnytsky S, Gaume A, Garvey A, Borisjuk N, Raskin I (2004) Quick and efficient system for antibiotic-free expression of heterologous genes in tobacco roots. Plant Cell Reports 22: 765-773
23. Komarnytsky S, Komarnytsky I (2004) Genetic variability among Solanum and Lycopersion species revealed by amplified fragment restriction polymorphysm analysis of chloroplast DNA. Cytol Genet 38(5): 9-15
2003
22. Komarnytsky S, Borisjuk N (2003) Functional analysis of promoter elements in plants. Genetic Engineering 25: 113-141. Kluwer Academic Publishers, New York
21. Gaume A, Komarnytsky S, Borisjuk N, Raskin I (2003) Rhizosecretion of recombinant proteins from plant hairy roots. Plant Cell Reports 21: 1188-1193
20. Komarnytsky S, Komarnytsky I (2003) Restriction variability of amplified chloroplast DNA fragments in the genus Nicotiana. Cytol Genet 37(1): 18-23
19. Komarnytsky S, Komarnytsky I (2003) Phylogenetic analysis of chloroplast DNA of 18 Solanaceae species. Cytol Genet 37(6): 17-22
2002
18. Komarnytsky S, Komarnytsky I (2002) Restriction polymorphism of amplified fragments of the genus Nicotiana chloroplast DNA. Biopolym Cell 18(6): 485-488
17. Raskin I, Ribnicky DM, Komarnytsky S, Ilic N, Poulev A, Borisjuk N, Brinker A, Moreno DA, Ripoll C, Yakoby N, O’Neal JM, Cornwell T, Pastor I, Fridlender B (2002) Plants and human health in the twenty-first century. Trends in Biotechnology 20: 522-531
16. Komarnytsky S, Komarnytsky I (2002) Amplification of randomly polymorphic DNA of American tobaccos from Petunioides subgenus. Biopolym Cell 18(4): 283-286
2001
15. Komarnytsky S, Komarnytsky I (2001) Phylogenetic tree of the australian species of Nicotiana based on the random amplified polymorphic DNA. Biopolym Cell 17(4): 278-282
14. Komarnytsky S (2001) Restriction enzyme mapping of ribosomal RNA genes of genus Nicotiana. Biopolym Cell 17(5): 380-387
2000
13. Komarnytsky S, Borisjuk N, Borisjuk L, Alam M, Raskin I (2000) Production of recombinant proteins in tobacco guttation fluid. Plant Physiology 124: 927-933
12. Borisjuk N, Borisjuk L, Komarnytsky S, Timeva S, Hemleben V, Gleba Yu, Raskin I (2000) Tobacco ribosomal DNA spacer element stimulates amplification and expression of heterologous genes. Nature Biotechnology 18: 1303-1306
11. Komarnytsky S, Komarnytsky I (2000) Organization and evolution of the Nicotiana 5S rRNA genes. Biopolym Cell 16(3): 205-211
10. Komarnytsky S (2000) Subrepeats of the intergenic spacer of Nicotiana ribosomal DNA. Biopolym Cell 16(2): 108-114
1999
9. Komarnytsky S (1999) An attempt to combine morphological characters and nuclear ribosomal DNA (internal transcribed spacer) sequences in phylogenetic studies in the genus Nicotiana. Biopolym Cell 15(5): 383-389
8. Komarnytsky S (1999) Restriction mapping of ribosomal DNA repeats of 18 Solanaceae species. Biopolym Cell 15(3): 213-218
1998
7. Komarnytsky S, Komarnytsky I, Cox A, Parokonny AS (1998) Molecular phylogeny of the nuclear 5.8S ribosomal RNA gene in 37 species of Nicotiana genus. Russian J Genet 34(7): 727-733
6. Komarnytsky S, Komarnytsky I, Cox A, Parokonny AS (1998) Evolution of sequences of the internal spacer of nuclear ribosomal DNA of American species of the genus Nicotiana. Cytol Genet 32(3): 69-76
5. Komarnytsky S (1998) Comparative analysis of 5.8S rDNA sequences from higher plants. Reports Natl Acad Sci Ukraine 1: 190-193
1997
4. Komarnytsky S (1997) Comparative analysis of nucleotide sequences of 5.8S nuclear ribosomal DNA of 30 plant species. Biopolym Cell 13(2): 150-156
3. Komarnytsky S, Komarnytsky I, Cox A, Parokonny AS (1997) Variation in 5.8S rDNA in some Solanaceae species. Cytol Genet 31(5): 11-19
2. Komarnytsky I, Komarnytsky S (1997) Variation in the intergenic spacer of ribosomal DNA of American species of tobacco. Cytol Genet 31(2): 29-36
1996
1. Komarnytsky I, Komarnytsky S (1996) Restriction fragment length polymorphism of the intergenic spacer of ribosomal DNA of some tobacco species. Cytol Genet 30(1): 65-72