We aim to understand the role of botanicals and gut microbiota in the development and potential management of metabolic dysfunction in obesity, diabetes, physical fitness, and inflamed states.
Metabolic dysfunction is on the rise as a result of major changes in socioeconomic lifestyles, cultural practices, and the challenges posed by the modern agricultural systems. These shifts are reshaping global diets, creating a pressing need to understand and develop new functional ingredients that provide both affordable and nutritious options in support of optimal health outcomes.
By investigating how plant-derived ingredients and microbial communities that digest them influence metabolic pathways, we seek to uncover novel strategies for targeted dietary interventions that enhance overall metabolic resilience.
By leveraging advanced pharmacogenomics and microbiome profiling, we aim to identify individualized approaches to management, offering more precise and effective interventions.
Within this overarching theme, our research focuses on three major initiatives:
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Among the many projects currently being pursued in our lab are the following:
Metabolic health and progression to obesity. Despite an obesogenic environment, some individuals exhibit obesity resistance, marked by efficient fat oxidation, enhanced mitochondrial function, and adaptive nutrient partitioning. Understanding the molecular and genetic drivers of this phenotype, and the potential modulatory role of small phenolic metabolites, can guide the development of targeted strategies for obesity prevention and treatment.
Gastrointestinal bitter receptors and blood glucose control. TAS2R receptors play an emerging role in the regulation of blood glucose by influencing hormone secretion, gastric motility, and nutrient absorption. Investigating how these receptors respond to dietary bitter compounds may reveal novel mechanisms for glycemic control and support the development of novel nutritional interventions for metabolic health.
Modern agricultural systems and human health outcomes. XXX
Mobile research platforms for discovery from nature (Mobile Discovery). XXX
Facilities
Our facilities consist of 3 functional units that offer a wide range of services to the research community, including cutting edge technologies, high end instrumentation, technical support, and education. Our lab personnel are highly trained experts in their field who provide technical expertise, consultation, and training. We are fully committed to enhancing and expanding the collaborative capabilities of research at NC State University, North Carolina Research Campus, and throughout the world.
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